The Gastroprotective Activity of Citrullus lanatus (Watermelon) Rind Flavonoid Extract on Aspirin- Induced Gastric Acid Secretion In Male Sprague-Dawley Rats (Rattus norvegicus)


  • Jan Harmony Cesar Cebu Doctors' University
  • Kim Marie Pearl S. Joe Cebu Doctors' University
  • Tessejim M. Alima Cebu Doctors' University
  • Eric John G. Canangca-an Cebu Doctors' University
  • Risen John S. Delos Reyes Cebu Doctors' University
  • Amanda Paige T. Winrock Cebu Doctors' University


Gastroprotective activity, flavonoid, watermelon, gastric acid secretion


This study determines the potential gastroprotective activity of the watermelon rind flavonoid extract by measuring the volume of gastric acid secreted by Sprague-Dawley rats. Twenty-one rats were utilized in the study and these were randomly assigned into three groups. The rats were weighed and their individual weights were used to calculate the dose of flavonoid extract, aspirin suspension, and omeprazole suspension to be administered. Aspirin suspension was used to induce gastric acid secretion in all three groups. Omeprazole suspension was given to the positive control group, distilled water to the negative control group, and flavonoid extract to the experimental group. After 1 hour, all rats underwent cervical dislocation and their gastric volumes were measured. The experimental group had the lowest mean gastric volume (0.19 mL), the positive control group came second (0.20 mL), and the negative control group had the highest mean gastric volume (0.67 mL). The flavonoid extract had the greatest effect in decreasing the gastric acid secretion of the test animals. The positive control group and experimental group showed no significant difference in gastric acid secretion (p value = 1). This shows that watermelon rind flavonoid extract exhibits an effect on gastric acid secretion similar to that of omeprazole.


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How to Cite

Cesar, J. H., Joe, K. M. P., Alima, T., Canangca-an, E. J., Delos Reyes, R. J., & Winrock, A. P. (2022). The Gastroprotective Activity of Citrullus lanatus (Watermelon) Rind Flavonoid Extract on Aspirin- Induced Gastric Acid Secretion In Male Sprague-Dawley Rats (Rattus norvegicus). Journal of Scientific Investigations, 1(1), 21–27. Retrieved from