Laboratory Assessment and Advancements in Hemostasis Testing During The Pandemic

Its Role in The Diagnosis of COVID-19-related Coagulopathies

Authors

  • Glenlyd Helmut Romanillos Cebu Doctors' University
  • Brian M. Denney Cebu Doctors' University
  • Emmalyn B. Cutamora Cebu Doctors' University

Keywords:

COVID-19-related coagulopathies, fibrinolysis testing, hemostasis testing, advancements in hemostasis

Abstract

Hemostasis is the physiological process by which blood flow is halted at the injury site to prevent excessive bleeding. Laboratory assessment of hemostasis refers to a series of tests that are performed to evaluate various components of this process, including platelet function, coagulation factors, and fibrinolysis. Overall, laboratory assessment of hemostasis is important for diagnosing and managing bleeding and clotting disorders. These tests can help identify the disorder's underlying cause and guide appropriate treatment. The COVID-19 pandemic has prompted some innovations and updates to the laboratory assessment of hemostasis, particularly concerning managing patients with COVID-19 who may be at increased risk of thrombosis.

References

Alice, D. Ma, Carrizosa, D. (2006).Acquired Factor VIII Inhibitors: Pathophysiology and Treatment. Hematology Am Soc Hematol Educ Program 2006, 2006(1), 432-437. https://doi.org/10.1182/asheducation-2006.1.432

Furie, B., Furie, B. C. (2020). Thrombosis and Antithrombotic Therapy. In: Kaushansky K, Lichtman MA, Prchal JT, Levi MM, Press OW, Burns LJ, Caligiuri MA, editors. Williams Hematology. 9th edition. McGraw-Hill.

Gerber, G., Chaturvedi, S (2021). How to recognize and manage COVID-19-associated coagulopathy. Hematology Am Soc Hematol Educ Program 2021. 2021(1), 614-620. https://doi.org/10.1182/hematology.2021000297

Furie, B. (2019, February 18). Bleeding and blood clotting. Encyclopedia Brittanica. https://www.britannica.com/science/hemostasis

Hoffman, R., Benz, E. J., Silberstein, L. E., Heslop, H., Weitz, J. I., & Anastasi, J. (2019). Hematology: Basic Principles and Practice (7th ed.). Elsevier.

Machlus, K. R., & Colleoni, M. W. (2018). Overview of fibrinolysis. In M. A. Lichtman, K. Kaushansky, J. T. Prchal, M. Levi, O. W. Press, & L. J. Burns (Eds.), Williams Hematology. 9th edition. McGraw-Hill.

Martinuzzo, M. E., & Blanco, A. N. (2014). Factor XI Deficiency. In R. A. Kadir (Ed.), Hemophilia and Hemostasis: A Case-Based Approach to Management (pp. 99-109). Springer.

Pavoni, V., Gianesello, L., & Pazzi, M. (2020). Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia. Journal of Thrombosis and Thrombolysis, 50(2), 281-286. https://doi.org/10.1007/s11239-020-02130-7

Peyvandi, F., Mannucci, P. M., & Garagiola, I. (2016). Clinical manifestations and management of severe hemophilia. In R. A. S. Kadir (Ed.), Hemophilia and Hemostasis: A Case-Based Approach to Management (pp. 53-71). Springer.

Rodak, B. F., Fritsma, G. A., & Keohane, E. M. (2015). Hematology: Clinical principles and applications (5th ed.). Elsevier Health Sciences.

Spyropoulos, A. C., Levy, J. H., Ageno, W., et al. (2020). Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. Journal of thrombosis and haemostasis: JTH, 18(8), 1859–1865. https://doi.org/10.1111/jth.14929

Tsantes, A. E., Frantzeskaki, F., Tsantes, A. G., et al. (2020). The haemostatic profile in critically ill COVID-19 patients receiving therapeutic anticoagulant therapy: An observational study. Medicine, 99(47), e23365. https://doi.org/10.1097/MD.0000000000023365

Verbruggen, B., Nováková, I., Wessels, H., Boezeman, J., Van den Berg, M., Mauser-Bunschoten, E. (1995). The Nijmegan modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability, 73(2), 247-251. https://doi.org.10.1055/s-0038-1653759

Wang, J., Hajizadeh, N., & Shore-Lesserson, L. (2022). The Value of Thromboelastography (TEG) in COVID-19 Critical Illness as Illustrated by a Case Series. Journal of cardiothoracic and vascular anesthesia, 36(8 Pt A), 2536–2543. https://doi.org/10.1053/j.jvca.2021.10.015

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Published

2023-12-15

How to Cite

Romanillos, G. H., Denney, B., & Cutamora, E. (2023). Laboratory Assessment and Advancements in Hemostasis Testing During The Pandemic: Its Role in The Diagnosis of COVID-19-related Coagulopathies. Journal of Scientific Investigations, 2(2), 8–16. Retrieved from https://jsi.cebudoctorsuniversity.edu/index.php/jsi/article/view/54

Issue

Section

Review Articles